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91.
Cigdem Guler Ebubekir Toy Firat Ozturk Dilek Gunes Aysun Bay Karabulut Onder Otlu 《The Angle orthodontist》2015,85(2):239
Objective:To determine the total oxidant status (TOS), total antioxidant status (TAS), and the 8-hydroxy-2′-deoxyguanosine (8-OHdG) levels and their interrelationship in the saliva of children undergoing fixed orthodontic therapy.Materials and Methods:Thirty children were randomly divided into three groups. The attachments were bonded to all of the teeth using three different orthodontic composites: Transbond XT, Kurasper F, and GrenGloo. The salivary levels of TOS, TAS, and 8-OHdG were determined three times, as follows: before treatment (T1) and at 1 month (T2) and 3 months (T3) following appliance placement. All data were statistically analyzed.Results:There were no significant differences in TOS, TAS, and 8-OHdG within the same time periods among the three different orthodontic composites (P > .05). TAS in all composite groups decreased over time. These decreases were found to be significant for Kurasper F and GrenGloo at the T1–T3 and T2–T3 time periods (P < .05). In all composite groups 8-OHdG decreased between T1 and T2 (P < .05). However, 8-OHdG in all composite groups increased from T2 to T3. These differences in 8-OHdG were significant in Kurasper F and GrenGloo (P < .05).Conclusions:Fixed orthodontic appliances bonded with the tested composites did not increase the cytotoxicity markers in saliva. 相似文献
92.
Dilek Sevimli Erkan Kozanoglu Rengin Guzel Ahmet Doganay 《Journal of Physical Therapy Science》2015,27(6):1781-1786
[Purpose] There are various treatment modalities for fibromyalgia syndrome (FMS), which
is characterized by widespread pain and fatigue. The aim of this study was to investigate
the effects of aquatic, aerobic and isometric strength-stretching exercises on the
physical and psychological parameters of patients with FMS. [Subjects and Methods] Seventy
five female patients with FMS were randomly selected and divided into three groups.
Patients (18–50 years) were treated for 3 months using one of three methods: a home-based
isometric strength and stretching exercise program (ISSEP), a gym-based aerobic exercise
program (AEP), and a pool-based aquatic aerobic exercise program (AAEP). Items evaluated
were: the number of tender points, Visual Analog Scale (VAS), Fibromyalgia Impact
Questionnaire (FIQ), the Six-Minute Walk Test (6MWT), SF-36 physical and mental health
scores, and the Beck Depression Inventory (BDI). [Results] The results revealed that AAEP
was the most effective treatment of the three. All of the groups showed significant
improvements in all variables between pre-and post-test, except the mean values of VAS and
BDI in ISSEP. [Conclusion] The results suggest that aquatic aerobic exercise program is
more effective than AEP and ISSEP in the treatment of FMS.Key words: Fibromyalgia, Exercise, Treatment 相似文献
93.
Demet Tekdos Demircioglu Nurdan Paker Elif Erbil Derya Bugdayci Tuluhan Yunus Emre 《Journal of Physical Therapy Science》2015,27(8):2501-2506
[Purpose] The aim of this study was to investigate the effect of the addition of NMES to
the post-TKA rehabilitation protocol on the functional status and quality of life of the
patients. [Subjects and Methods] Patients were randomized into an exercise (control) and
electrical stimulation (NMES) group. A home exercise program was prescribed for the
control group. For the neuromuscular stimulation group 30 minute electrical stimulation
applied to the vastus medialis muscle 5 days a week for 4 to 6 weeks. VAS, the timed up
and go test, WOMAC and SF-36 scores were evaluated preoperatively and postoperatively at
the first month and the third month of the follow-up period. [Results] Both the NMES group
had 30 patients each, with 2 and 1 male patients respectively. The comparisons of WOMAC
results at month 1 revealed that pain, stiffness, and total scores of the NMES group was
significantly better than those of control group at the first and third months.
Significantly better physical function and SF-36 subscales, except mental health, were
found for the NMES group at the first month of follow-up. [Conclusion] The inclusion of
the neuromuscular electrical stimulation program after knee arthroplasty was more
effective at providing rapid improvements in knee pain, walking distance and quality of
life.Key words: Quadriceps muscle, Knee joint, Arthroplasty 相似文献
94.
Hulya Iliksu Gozu Sandra Mueller Rifat Bircan Knut Krohn Gazenfer Ekinci Dilek Yavuzer Haluk Sargin Mehmet Sargin Tunc Ones Cem Gezen Ekrem Orbay Beyazit Cirakoglu Ralf Paschke 《Thyroid》2008,18(5):499-508
BACKGROUND: Up to date, three thyroid-stimulating hormone receptor (TSHR) germline variants have been reported for which no functional consequences have been detected by in vitro characterizations. However, familial nonautoimmune hyperthyroidism and hot nodules are clearly associated with constitutively activating TSHR germline mutations. We describe a family with a new TSHR germline mutation that is associated with euthyroidism in 13 family members and hyperthyroidism in 1 family member. METHODS: Mutation analysis of the TSHR gene was performed by denaturing gradient gel electrophoresis. TSHR constructs were characterized by determination of cell surface expression, 3'-5'-cyclic adenosine monophosphate (cAMP) accumulation, and constitutive cAMP activity. RESULTS: A novel TSHR germline mutation (N372T) was found in a man who presented with thyrotoxicosis. The mutation was also detected in 13 family members, all of whom were euthyroid. Interestingly, an additional constitutively active somatic mutation (S281N) was identified on the second parental TSHR allele of the hyperthyroid index patient. Linear regression analysis showed a lack of constitutive activity for N372T. Moreover, coexpression studies of N372T with S281N did not reveal any evidence for a functional influence of N372T on the constitutively active mutation (CAM). CONCLUSIONS: N372T is unlikely to cause altered thyroid function. This is consistent with the finding that only the index patient with the additional somatic mutation S281N was hyperthyroid. 相似文献
95.
Oytun Erbaş Hüseyin Serdar Akseki Volkan Solmaz Hüseyin Aktuğ Dilek Taşkıran 《The Kaohsiung journal of medical sciences》2014,30(9):447-452
Although understanding the relation between psychotic behavior and immune abnormalities has been the focus of research for many years, it remains to be elucidated whether the changes in cytokine levels are part of etiology or a result of the stress associated with the disorder. In accordance with previous studies on changes in cytokine levels due to metabolic changes and psychosis, we hypothesized that fatty liver may potentiate apomorphine-induced stereotypy in a rodent model and that a synthetic glucagon-like peptide-1 analog exenatide would ameliorate this effect. In this study, 18 male Sprague Dawley albino mature rats were used. We induced hepatosteatosis in these rats by feeding them with 30% fructose dissolved in drinking water for 8 weeks. The animals were divided into three groups, namely, the normal group, the intracerebroventricular (ICV) exenatide group, and the ICV NaCl group. Apomorphine-induced stereotypic behavior test was performed in all groups and the liver was removed for histopathological examination after all the rats were euthanized. In the nonalcoholic fatty liver (NAFL) group, stereotypy scores were significantly increased compared with the control group rats (p < 0.00001). A significant decrease in stereotypy scores were observed in the ICV exenatide group with NAFL when compared with the ICV saline group with NAFL (p < 0.005). In addition, brain malondialdehyde and tumor necrosis factor-α levels decreased in the ICV exenatide group. The results of this study showed that fatty liver enhances the effect of apomorphine on stereotypy, which was reversed by exenatide possibly by antioxidant and anti-inflammatory effects. 相似文献
96.
Aziz Homayouni Rad Haniyeh Rasouli Pirouzian Nevzat Konar Omer Said Toker Derya Genc Polat 《RSC advances》2019,9(51):29676
Sucrose-free milk chocolates containing different types of bulk (isomalt, xylitol and maltitol) and high intensity (Stevia) sweeteners were produced by using a ball mill. The main quality characteristics of the formulated chocolates were evaluated and compared with those of the conventional sample containing sucrose. The Casson model was the best fitting model for the rheological data. Casson viscosity and Casson yield stress were significantly affected by the type of bulking agent in chocolates formulated with xylitol (p < 0.05). However xylitol notably improved the overall acceptability according to the sensory analysis results. Chocolates containing the sucrose replacers demonstrated lower Tonset values and higher enthalpy than the control sample. Sucrose-free chocolates illustrated a higher degree of particle agglomeration. Bulk sweeteners meanwhile seem to have high potential for milk chocolate production with low calorie values by using the ball mill technique. Industrial applications: the production of sucrose-free chocolates with conventional methods requires a lot of time and energy. Recently, using alternative methods for chocolate production has been raising interest in many small industries. This study proposed a ball mill method for the preparation of sucrose-free milk chocolates with physiochemical properties almost ranging in the standard limit defined for chocolate. Although using the ball mill method presents a more cost-effective technique for chocolate production and provides shorter processing times for small chocolate industries, it seems to be less efficient in evaporating moisture than the conventional processing. Challenges are still ahead for upgrading this alternative technique to be efficient in evaporating more moisture during operation ending in a high quality product.Sucrose-free milk chocolates containing different types of bulk (isomalt, xylitol and maltitol) and high intensity (Stevia) sweeteners were produced by using a ball mill. 相似文献
97.
Nilgun Karadag Serdar Beken Dilek Dilli Aysegul Zenciroglu Nurullah Okumus 《Indian journal of pediatrics》2014,81(8):803-804
Despite advances in the neonatal care, hypoxic ischemic encephalopathy in late preterm and term infants remains an important cause of morbidity and mortality. There is lack of data on the application of therapeutic hypothermia in the existence of severe skin lesions. Epidermolysis bullosa is a rare group of inherited conditions which causes blisters in skin and mucosal membranes. In this report, the authors describe a successful whole-body hypothermia treatment of severe hypoxic ischemic encephalopathy in a term newborn with dystrophic epidermolysis bullosa. They observed that therapeutic hypothermia may also be given in newborns with dystrophic epidermolysis bullosa without any complications. 相似文献
98.
Nafiye Urganci Merve Usta Derya Kalyoncu Emirzad Demirel 《Indian journal of pediatrics》2014,81(7):675-679
Objectives
To evaluate children who ingested corrosive substances, in terms of demographic features, nature of ingested substances, clinical findings, management and complications.Methods
A total of 1709 cases aged between 0 and 16 y who ingested corrosive substance were analyzed retrospectively by evaluating the medical records of the patients.Results
The mean age of the cases was 35.23?±?30.65 mo and male:female ratio was 1.45. Forty one percent of corrosive substances causing intoxication contained NaOH. Thirty percent of the families consisted of 5 or more members. Fourteen percent of the mothers were illiterate. Stricture formation was observed in 29 (1.69 %) of the cases during follow-up. In 79.31 % of those cases alkaline substance ingestion was responsible for stricture development. It was found that stricture formation occurred more frequently among cases who were older than 5 y of age and this finding was statistically significant (p?=?0.001).Conclusions
The cases older than 5 y of age with the diagnosis of grade 2b esophagitis must be followed up closely for the stricture formation. In order to protect children from corrosive ingestion, importance must be given to preventive measures such as education of families, keeping and storing these agents out of the reach of children and providing safety caps for these products. 相似文献99.
Fadime Canbolat Dilek Meltem Tasdemir Erin Alper Evrensel Ahmet Aydn Kaif Nevzat Tarhan 《Basic & clinical pharmacology & toxicology》2019,124(3):285-297
Therapeutic drug monitoring (TDM) is used to determine the concentration of drug in plasma/serum to adjust the dose of the therapeutic drug. Selective and sensitive analytical methods are used to determine drug and metabolite levels for the successful application of TDM. The aim of the study was to develop and validate using LC‐MS/MS to analyse quantitative assay of escitalopram (S‐CT) and metabolites in human plasma samples. In order to provide a convenient and safe treatment dose, it was aimed to determine the levels of S‐CT and its metabolites in the patients’ plasma. A new method with short sample preparation and analysis time was developed and validated using LC‐MS/MS to analyse quantitative assay of S‐CT and its metabolites in plasma. Also, plasma samples of 30 patients using 20 mg S‐CT between the ages of 18 and 65 years were analysed by the validated method. The mean values of S‐CT, demethyl escitalopram and didemethyl escitalopram in plasma of patients were 27.59, 85.52 and 44.30 ng/mL, respectively. At the end of the analysis, the metabolic ratio of S‐CT and metabolites was calculated. It is considered that the method for the quantitative analysis of S‐CT and its metabolites in human plasma samples may contribute to the literature on account of its sensitive and easy application. Additionally, the use of our data by physicians will contribute to the effective drug treatment for their patients who take S‐CT. 相似文献
100.
Ozlem Altuntas Aydin Mucahit Yemisen Hayat Kumbasar Karaosmanoglu Fatma Sargin Alper Gunduz Bahadir Ceylan Bilgul Mete Nail Ozgunes Dilek Yildiz Sevgi Resat Ozaras Fehmi Tabak 《Hepatitis monthly》2014,14(8)